Send to

Choose Destination
FEMS Microbiol Ecol. 2018 Dec 1;94(12). doi: 10.1093/femsec/fiy195.

Environmental dimensions of antibiotic resistance: assessment of basic science gaps.

Author information

Julius Kühn-Institut Federal Research Centre for Cultivated Plants, Institute for Epidemiology and Pathogen Diagnostics, Messeweg 11-12, 38104 Braunschweig, Germany.
Bacterial Epidemiology and Antimicrobial Resistance Research Unit, U.S. National Poultry Research Center, USDA Agricultural Research center, 950 College Station Road, Athens GA 306052720, USA.
ithree institute, University of Technology Sydney, PO Box 123, Broadway, Sydney, NSW 2007 Australia.
ESI & CEC, Biosciences, University of Exeter, Penryn Campus, Cornwall, TR10 9FE, UK.
Department of Biological Sciences, Macquarie University, Sydney, NSW 2109, Australia.


Antibiotic resistance is one of the major problems facing medical practice in the 21st century. Historical approaches to managing antibiotic resistance have often focused on individual patients, specific pathogens and particular resistance phenotypes. However, it is increasingly recognized that antibiotic resistance is a complex ecological and evolutionary problem. As such, understanding the dynamics of antibiotic resistance requires integration of data on the diverse mobile genetic elements often associated with antibiotic resistance genes, and their dissemination by various mechanisms of horizontal gene transfer between bacterial cells and environments. Most important is understanding the fate and effects of antibiotics at sub-inhibitory concentrations, and co-selection. This opinion paper identifies key knowledge gaps in our understanding of resistance phenomena, and outlines research needs that should be addressed to help us manage resistance into the future.


Supplemental Content

Full text links

Icon for Silverchair Information Systems
Loading ...
Support Center