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Chem Commun (Camb). 2018 Oct 25;54(83):11753-11756. doi: 10.1039/c8cc07328g. Epub 2018 Oct 2.

1,4-Conjugate addition/esterification of ortho-quinone methides in a multicomponent reaction.

Author information

1
Institute of Drug Discovery and Design, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, P. R. China. slcui@zju.edu.cn.

Abstract

A novel 1,4-conjugate addition/esterification of ortho-quinone methides in a multicomponent reaction has been developed. In this protocol, numerous carboxylic acids, ynamides and in situ generated ortho-quinone methides could assemble rapidly to constitute this process for the synthesis of functionalized 3,3-diarylpropanamides with sufficient structural diversity. Furthermore, the products could be transformed to an array of compounds.

PMID:
30276381
DOI:
10.1039/c8cc07328g

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