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J Exerc Rehabil. 2018 Aug 24;14(4):680-687. doi: 10.12965/jer.1836132.066. eCollection 2018 Aug.

Functional capacity and ventilatory efficiency are preserved in well-controlled people living with human immunodeficiency virus/acquired immunodeficiency syndrome.

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Post Graduation Program in Health Sciences, Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Porto Alegre, Brazil.
Physical Education Department, Health Sciences Institute, Universidade Federal de Juiz de Fora, Governador Valadares, Brazil.
Physical Therapy Department, Universidade do Estado de Santa Catarina (UDESC), Florianópolis, Brazil.
Physical Therapy Department, UFCSPA, Porto Alegre, Brazil.
Nursing Department, Universidade do Vale do Rio dos Sinos, São Leopoldo, Brazil.
Health Secretariat of State of Rio Grande do Sul, Porto Alegre, Brazil.


To verify and compare the responses of the cardiopulmonary variables to the incremental test in physically inactive people living with human immunodeficiency virus (HIV)/acquired immune deficiency syndrome (AIDS) (PLWHA) with well-controlled disease and physically inactive healthy subjects (non-HIV/AIDS). Participants performed a cardiopulmonary exercise test (CPX) on a treadmill. Data were analyzed using the Mann-Whitney test and Spearman correlation. Nine PLWHA (5 women) and 9 non-HIV/AIDS gender and activity level-matched controls were included in the data analysis. Data are expressed in median (range). No difference was shown in the PLWHA group when compared to the control group in functional capacity (peak oxygen consumption [VO2peak]: 29.9 (20.9-36.4) mL/kg/min vs. 32.2 (24.5-39.4) mL/kg/min) and ventilatory efficiency (oxygen uptake efficiency slope [OUES]: 2,058 [1,474-3,204] vs. 2,612 [1,383-4,119]; minute ventilation carbon dioxide production slope: 27.4 [22.5-33.6] vs. 27.5 [20.4-38.1]). The results are also similar to maximal heart rate, oxygen pulse, gas exchange threshold, respiratory compensation point, heart rate recovery, and half-time of VO2peak recovery. OUES had a strong correlation with VO2peak in the PLWHA group (r s =0.70, P=0.04) and control group (r s =0.78, P=0.02). The results of this study indicate that functional capacity and ventilatory efficiency in PLWHA with well-controlled disease are preserved and are not different from sedentary subjects. In this sense, when CPX is unavailable, the aerobic assessment and prescription could be based on simpler procedures used in healthy subjects.


Acquired immune deficiency syndrome; Cardiopulmonary exercise test; Human immunodeficiency virus; Oxygen consumption; Oxygen uptake efficiency slope; VE/VCO2 slope

Conflict of interest statement

CONFLICT OF INTEREST No potential conflict of interest relevant to this article was reported.

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