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Mater Sci Eng C Mater Biol Appl. 2018 Dec 1;93:505-517. doi: 10.1016/j.msec.2018.08.033. Epub 2018 Aug 13.

Effect of С60 fullerenes on the intensity of colon damage and hematological signs of ulcerative colitis in rats.

Author information

1
Taras Shevchenko National University of Kyiv, 64/13, Volodymyrska str., 01601 Kyiv, Ukraine. Electronic address: byelinska@univ.kiev.ua.
2
Taras Shevchenko National University of Kyiv, 64/13, Volodymyrska str., 01601 Kyiv, Ukraine.
3
Taras Shevchenko National University of Kyiv, 64/13, Volodymyrska str., 01601 Kyiv, Ukraine; Joint Institute for Nuclear Research, Dubna, Moscow Region, Russia.
4
Joint Institute for Nuclear Research, Dubna, Moscow Region, Russia.
5
Technical University of Ilmenau, Institute of Chemistry and Biotechnology, 25 Weimarer str., 98693 Ilmenau, Germany.

Abstract

The application of pristine С60 fullerene aqueous colloid solution (C60FAS; 0.5 mg/kg body weight) for rats experienced acute colitis, either intraperitoneally or intrarectally (1) restores the colonic mucosa healing and epithelial barrier integrity, evidenced by autopsies and histological findings and the normalization of phenolsufonphthalein dye daily excretion; (2) attenuates the consequences of hemorrhages, such as signs of anemia and increased platelet count; (3) improves the liver redox status suppressing the lipid peroxidation (malonic dialdehyde and protein carbonyl group levels tended down) and stimulating the antioxidant defense system (glutathione peroxidase activity grew up). In addition, C60FAS intrarectally increases the monocyte count and decreases content of neutrophil granulocytes, i.e. diminishes the rate of the inflammatory process and activates the processes of colon tissues restoring with monocytes involvement. Therefore, intrarectal administration of C60FAS may serve as an efficient tool of ulcerative colitis therapy.

KEYWORDS:

Acute colitis; Antioxidant defense system; Colonic mucosa; Platelets; Red and white blood cells; С(60) fullerene

PMID:
30274084
DOI:
10.1016/j.msec.2018.08.033
[Indexed for MEDLINE]

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