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Brain Behav. 2018 Nov;8(11):e01101. doi: 10.1002/brb3.1101. Epub 2018 Oct 1.

Effect of electroconvulsive therapy on brain-derived neurotrophic factor levels in patients with major depressive disorder.

Author information

1
Department of Psychiatry, Tampere University Hospital, Tampere, Finland.
2
Department of Psychiatry, School of Medicine, University of Tampere, Tampere, Finland.
3
Department of Psychiatry, Seinäjoki Hospital District, Seinäjoki, Finland.
4
Department of Neurosurgery, Neurology and Rehabilitation, Tampere University Hospital, Tampere, Finland.
5
The Immunopharmacology Research Group, Faculty of Medicine and Life Sciences, University of Tampere and Tampere University Hospital, Tampere, Finland.

Abstract

OBJECTIVES:

Brain-derived neurotrophic factor (BDNF) has been associated with depression and its treatment response. The aim of the present study was to explore the effect of electroconvulsive therapy (ECT) on serum and plasma BDNF levels and change of Montgomery-Asberg Depression Rating Scale (MADRS) and their associations in patients with major depressive disorder (MDD).

METHODS:

The study included thirty patients suffering from MDD. Their serum and plasma BDNF levels were examined before ECT (baseline) and after the first, fifth, and last ECT session. The severity of the depression and the response to ECT were measured with MADRS.

RESULTS:

Electroconvulsive therapy caused no significant changes in serum BDNF levels. Plasma BDNF levels decreased during the fifth ECT session between the baseline and the 2-hr samples (p = 0.019). No associations were found between serum or plasma BDNF levels and remission. The correlations between plasma and serum BDNF levels in each measurement varied between 0.187 and 0.636.

CONCLUSIONS:

Neither serum nor plasma BDNF levels were systematically associated with the clinical remission. However, the plasma BDNF levels somewhat varied during the ECT series. Therefore, the predictive value of BDNF for effects of ECT appears to be at least modest.

KEYWORDS:

brain-derived neurotrophic factor; electroconvulsive therapy; major depressive disorder; neurotrophin

PMID:
30273985
PMCID:
PMC6236235
DOI:
10.1002/brb3.1101
[Indexed for MEDLINE]
Free PMC Article

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