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Nutrition. 2019 Feb;58:1-6. doi: 10.1016/j.nut.2018.05.028. Epub 2018 Jul 11.

Effects of a leucine-enriched amino acid supplement on muscle mass, muscle strength, and physical function in post-stroke patients with sarcopenia: A randomized controlled trial.

Author information

1
Department of Rehabilitation Medicine, Kumamoto Rehabilitation Hospital, Kumamoto, Japan. Electronic address: hanley.belfus@gmail.com.
2
Department of Rehabilitation, Kumamoto Rehabilitation Hospital, Kumamoto, Japan.
3
Department of Nutritional Management, Kumamoto Rehabilitation Hospital, Kumamoto, Japan.
4
Department of Consumer Foods & Seasonings, Food Products Division, Ajinomoto Co., Inc., Tokyo, Japan.

Abstract

OBJECTIVES:

The aim of this study was to investigate the effects of a leucine-enriched amino acid supplement on muscle mass, muscle strength, and physical function in post-stroke patients with sarcopenia.

METHODS:

We conducted an eight-wk, two-parallel group intervention, randomized controlled, blinded outcome assessment among 44 post-stroke older patients with sarcopenia. Sarcopenia was defined as a loss of skeletal muscle mass and decreased muscle strength according to the Asian Working Group for Sarcopenia criteria. The intervention group (n = 21) received a leucine-enriched amino acid supplement; the control group (n = 23) did not. Both groups performed low-intensity resistance training in addition to a post-stroke rehabilitation program. A primary outcome of physical function by using the motor domain of Functional Independence Measure (FIM), and secondary outcomes of appendicular muscle mass (skeletal muscle mass index [SMI]) measured via bioelectrical impedance analysis and muscle strength as handgrip strength were measured at baseline and at the end of the intervention.

RESULTS:

The FIM score increased significantly in both groups over time (P < 0.01), with significantly greater improvement in the intervention group than in the control group (P < 0.045). Handgrip strength also increased significantly over time (P <0.05), with significantly greater improvement in the intervention group (P < 0.01). The SMI increased significantly in the intervention group but not in the control group over time, with significantly greater improvement in the intervention group (median estimated difference, 0.50 kg/m2; 95% confidence interval, 0.01-2.11).

CONCLUSIONS:

We demonstrated that an eight-wk intervention consisting of a leucine-enriched amino acid supplementation and low-intensity resistance training increased muscle mass, strength, and physical function in post-stroke patients with sarcopenia.

KEYWORDS:

Elderly; Leucine; Nutrition; Rehabilitation; Sarcopenia; Stroke

PMID:
30273819
DOI:
10.1016/j.nut.2018.05.028
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