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Hum Brain Mapp. 2018 Dec;39(12):5112-5125. doi: 10.1002/hbm.24349. Epub 2018 Oct 1.

Rostro-caudal organization of the human posterior superior temporal sulcus revealed by connectivity profiles.

Cheng C1,2, Fan L2,3, Xia X1,2, Eickhoff SB4,5, Li H2,3, Li H1, Chen J1, Jiang T2,3,6,7,8.

Author information

1
College of Computer Science and Technology, Taiyuan University of Technology, Taiyuan, China.
2
Brainnetome Center, Institute of Automation, Chinese Academy of Sciences, Beijing, China.
3
University of Chinese Academy of Sciences, Beijing, China.
4
Institute of Systems Neuroscience, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
5
Institute of Neuroscience and Medicine, Brain & Behaviour (INM-7), Research Centre Jülich, Jülich, Germany.
6
CAS Center for Excellence in Brain Science and Intelligence Technology, Institute of Automation, Chinese Academy of Sciences, Beijing, China.
7
National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing, China.
8
The Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia.

Abstract

The posterior superior temporal sulcus (pSTS) plays an important role in biological motion perception but is also thought to be essential for speech and facial processing. However, although there are many previous investigations of distinct functional modules within the pSTS, the functional organization of the pSTS in its full functional heterogeneity has not yet been established. Here we applied a connectivity-based parcellation strategy to delineate the human pSTS subregions based on distinct anatomical connectivity profiles and divided it into rostral and caudal subregions using diffusion tensor imaging. Subsequent multimodal connection pattern analyses revealed distinct subregional connectivity profiles. From this we inferred that the two subregions are involved in distinct functional circuits, the language processing loop and the cognition attention network. These results indicate a convergent functional architecture of the pSTS that can be revealed based on different types of connectivity and is reflected in different functions and interactions. In addition, when the subregions were performing their processing in the different functional circuits, we found asymmetry in the bilateral pSTS. Our findings may improve the understanding of the functional organization of the pSTS and provide new insights into its interactions and integration of information at the subregional level.

KEYWORDS:

connectivity-based parcellation; pSTS; parcellation; tractography

PMID:
30273447
DOI:
10.1002/hbm.24349

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