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Asia Pac J Clin Nutr. 2018;27(5):1031-1039. doi: 10.6133/apjcn.042018.05.

Pro- and prebiotic effects on oxidative stress and inflammatory markers in non-alcoholic fatty liver disease.

Author information

1
Nutrition Research Center, Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
2
Liver and Gastrointestinal Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
3
Road Traffic Injury Research Center, Department of Biostatistics and Epidemiology, Tabriz, Iran.
4
Faculty of Paramedical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
5
Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
6
Nutrition Research Center, Department of Biochemistry and Diet Therapy, Faculty of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran. bahrampg@yahoo.com; pourghassemb@tbzmed.ac.ir.

Abstract

BACKGROUND AND OBJECTIVES:

Non-alcoholic fatty liver disease (NAFLD) is related to inflammation and oxidative stress. Probiotics and prebiotics are considered anti-inflammatory and antioxidative factors. In this study, we evaluated the effects of probiotic and/or prebiotic on oxidative stress and inflammatory markers in patients with NAFLD.

METHODS AND STUDY DESIGN:

Seventy-five NAFLD subjects were divided into four groups. The first group received a pro-biotic capsule of Bifidobacterium longum (B.L) and Lactobacillus acidophilus (L.A) (2 × 107 CFU/day), the second group received prebiotic (10 g/day inulin), the third group received pro-biotic and prebiotic, and the fourth group received placebo, for three months. Anthropometric, inflammatory and oxidative/ anti-oxidative indices were measured in all patients before and after the intervention.

RESULTS:

We showed that consumption of pro- and/or prebiotic compared to placebo is able to significantly decrease body weight, body mass index, waist and hip circumferences, tumour necrosis factor-α and increase serum levels of total antioxidant capacity in patients with NAFLD (p<0.01). There were not any significant differences between probiotic, prebiotic and co-administration of them on the mentioned parameters. Co-administration of pro- and prebiotic caused significant decrease of high-sensitive C-reactive protein (hs-CRP) compared to the placebo and other groups (p<0.01). Interlekin-6 and malondialdehyde were not significantly different among groups at the end of study.

CONCLUSIONS:

Probiotic or/and prebiotic supplementation can be effective for improvement of some anthropometric, inflammatory and oxidative indices in patients with NAFLD. Co-administration of pro- and prebiotic is more effective than probiotic and prebiotic alone in modifying hs-CRP in patients with NAFLD.

PMID:
30272851
DOI:
10.6133/apjcn.042018.05
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