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J Gen Virol. 1987 Jan;68 ( Pt 1):115-22.

Reassortment of human rotavirus possessing genome rearrangements with bovine rotavirus: evidence for host cell selection.

Abstract

Mixed infections of secondary rhesus monkey kidney cells with human rotaviruses carrying rearranged genomes and with bovine rotavirus yielded a high percentage of reassortants. The genotypes of 511 plaque-purified clones raised in either MA104 or BSC-1 cells have been determined and the frequencies of different genotypes have been calculated. It was found that reassortants did not emerge at random; there was non-random association of certain genes; the cell line used to isolate reassortants influenced the result, i.e. host cell factors had a selective effect on a recombinational mixture.

PMID:
3027239
DOI:
10.1099/0022-1317-68-1-115
[Indexed for MEDLINE]

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