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Evid Based Complement Alternat Med. 2018 Sep 9;2018:7931849. doi: 10.1155/2018/7931849. eCollection 2018.

Ozone Therapy as Adjuvant for Cancer Treatment: Is Further Research Warranted?

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Research Unit, Dr. Negrín University Hospital, Las Palmas, Spain.
Radiation Oncology Department, Dr. Negrín University Hospital, Las Palmas, Spain.
Chronic Pain Unit of the Dr. Negrín University Hospital, Las Palmas, Spain.
Instituto Universitario de Investigaciones Biomédicas y Sanitarias (IUIBS), Grupo BIOPHARM, Universidad de Las Palmas de Gran Canaria, Las Palmas, Spain.
Grupo de Investigación Clínica en Oncología Radioterápica (GICOR), Madrid, Spain.
Section of Thoracic Surgery, Department of Surgery, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.
Experimental Medicine and Surgery Unit of Hospital Gregorio Marañón and the Health Research Institute of Hospital Gregorio Marañón (IiSGM), Madrid, Spain.
Servicio Atención Especializada, Dirección General de Programas Asistenciales, Servicio Canario de Salud, Las Palmas, Spain.
Unidad de Ozonoterapia, Hospital Quirónsalud, Barcelona, Spain.
University of Saint George, Italy.
Clinicanaria Internacional, Las Palmas, Spain.
Department of Nuclear Medicine, DIMEC Center, Clínica San Roque, Las Palmas, Spain.



This article provides an overview of the potential use of ozone as an adjuvant during cancer treatment.


We summarize the findings of the most relevant publications focused on this goal, and we include our related clinical experience.


Over several decades, prestigious journals have published in vitro studies on the capacity of ozone to induce direct damage on tumor cells and, as well, to enhance the effects of radiotherapy and chemotherapy. Indirect effects have been demonstrated in animal models: immune modulation by ozone alone and sensitizing effect of radiotherapy by concurrent ozone administration. The effects of ozone in modifying hemoglobin dissociation curve, 2,3-diphosphoglycerate levels, locoregional blood flow, and tumor hypoxia provide additional support for potential beneficial effects during cancer treatment. Unfortunately, only a few clinical studies are available. Finally, we describe some works and our experience supporting the potential role of local ozone therapy in treating delayed healing after tumor resection, to avoid delays in commencing radiotherapy and chemotherapy.


In vitro and animal studies, as well as isolated clinical reports, suggest the potential role of ozone as an adjuvant during radiotherapy and/or chemotherapy. However, further research, such as randomized clinical trials, is required to demonstrate its potential usefulness as an adjuvant therapeutic tool.

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