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J Neurosci Rural Pract. 2018 Oct-Dec;9(4):616-618. doi: 10.4103/jnrp.jnrp_515_17.

A Case Report of Misdiagnosis of Psychotic Symptoms Predominant Wilson's Disease.

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Department of Internal Medicine, B.P. Koirala Institute of Health Sciences, Dharan, Nepal.
Department of Psychiatry, B.P. Koirala Institute of Health Sciences, Dharan, Nepal.


Wilson's disease is an autosomal recessive disease of abnormal copper metabolism. Psychosis is a rare manifestation of Wilson's disease. Few cases of misdiagnosing Wilson's disease as an etiology of psychosis were reported in the literature. We report a case of a 42-year-old patient, who was diagnosed with a schizoaffective disorder and treated with antipsychotics for 3 years with no significant improvement. On reevaluation, we the patient was diagnosed to have Wilson's disease. The patient's symptoms improved significantly with chelation therapy.


Misdiagnosis; Wilson's disease; psychosis

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