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Indian J Nephrol. 2018 Sep-Oct;28(5):393-396. doi: 10.4103/ijn.IJN_262_17.

Late Posttransplant Lymphoproliferative Disease: Report of a Rare Case and Role of Positron Emission Tomography-computed Tomography.

Author information

1
Department of Urology and Renal Transplantation, SGPGIMS, Lucknow, Uttar Pradesh, India.
2
Department of Nuclear Medicine, SGPGIMS, Lucknow, Uttar Pradesh, India.
3
Department of Nephrology, SGPGIMS, Lucknow, Uttar Pradesh, India.
4
Department of Radiology, SGPGIMS, Lucknow, Uttar Pradesh, India.

Abstract

Posttransplant lymphoproliferative disease (PTLD) is an uncommon complication of immunosuppression after solid organ transplantation. Early PTLD (<1 year after transplantation) is frequently found around the allograft, whereas late PTLD (>1 year after transplantation) does not have such a preference. 18-Fluorodeoxyglucose positron emission tomography-computed tomography (18FDG PET-CT) has clinical significance in the evaluation of PTLD. 18FDG PET-CT scan allows precise anatomic localization of FDG-avid lesions, hence helpful in staging of disease and evaluation of response to therapy. It can better characterize persistent lesions and differentiate residual tumor from fibrosis or necrosis. We present a rare case report of a perigraft PTLD developing 12 years after renal transplantation sparing the graft, in an Epstein-Barr virus-negative patient.

KEYWORDS:

18-fluorodeoxyglucose positron emission tomography-computed tomography; chemotherapy; posttransplant lymphoproliferative disease

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