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Indian J Nephrol. 2018 Sep-Oct;28(5):393-396. doi: 10.4103/ijn.IJN_262_17.

Late Posttransplant Lymphoproliferative Disease: Report of a Rare Case and Role of Positron Emission Tomography-computed Tomography.

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Department of Urology and Renal Transplantation, SGPGIMS, Lucknow, Uttar Pradesh, India.
Department of Nuclear Medicine, SGPGIMS, Lucknow, Uttar Pradesh, India.
Department of Nephrology, SGPGIMS, Lucknow, Uttar Pradesh, India.
Department of Radiology, SGPGIMS, Lucknow, Uttar Pradesh, India.


Posttransplant lymphoproliferative disease (PTLD) is an uncommon complication of immunosuppression after solid organ transplantation. Early PTLD (<1 year after transplantation) is frequently found around the allograft, whereas late PTLD (>1 year after transplantation) does not have such a preference. 18-Fluorodeoxyglucose positron emission tomography-computed tomography (18FDG PET-CT) has clinical significance in the evaluation of PTLD. 18FDG PET-CT scan allows precise anatomic localization of FDG-avid lesions, hence helpful in staging of disease and evaluation of response to therapy. It can better characterize persistent lesions and differentiate residual tumor from fibrosis or necrosis. We present a rare case report of a perigraft PTLD developing 12 years after renal transplantation sparing the graft, in an Epstein-Barr virus-negative patient.


18-fluorodeoxyglucose positron emission tomography-computed tomography; chemotherapy; posttransplant lymphoproliferative disease

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