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Indian J Nephrol. 2018 Sep-Oct;28(5):389-392. doi: 10.4103/ijn.IJN_102_17.

Early Eosinophilic Antibody-mediated Rejection in a Renal Allograft Recipient.

Author information

1
Department of Nephrology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.
2
Department of Pathology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.

Abstract

Although the predominant component of acute allograft rejection is the T-cells, the milieu is not devoid of other inflammatory cells including plasma cells, eosinophils, and histiocytes. Apart from the CD8 T cell and CD4 T cell-FasL cytotoxicity, experimental models had proven a pivotal role of Th-2 cells in acute rejection, and these have been associated with marked tissue eosinophilia. Herein, we present a unique case of severe eosinophilic acute antibody-mediated rejection in a 22 years old deceased donor renal allograft recipient, within 4 days of transplantation without peripheral eosinophilia. The pathology was successfully dealt with the prevailing modalities of therapy, including steroids, plasmapheresis, intravenous immunoglobulin, and bortezomib. Concurrently, we have briefly reviewed the literature about the role of eosinophils in graft rejection and its prognostication.

KEYWORDS:

Antibody-mediated rejection; cluster designation; intravenous immunoglobulin; peritubular capillaritis

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