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Arch Physiol Biochem. 2018 Sep 29:1-8. doi: 10.1080/13813455.2018.1502323. [Epub ahead of print]

Consumption of Spinacia Oleracea (spinach) and aerobic exercise controls obesity in rats by an inhibitory action on pancreatic lipase.

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a Department of Pharmacology & Toxicology, Prin. K. M. Kundnani College of Pharmacy , Mumbai , India.
b Department of Pharmacognosy, SVKM's NMIMS, School of Pharmacy & Technology Management , Mukesh Patel Technology Park , Shirpur , India.



Spinaciaoleracea (spinach) is abundant in antioxidant phytoconstituents, termed as the natural antioxidant mixture (NAO).


This study evaluates the anti-hyperlipidemicand anti-obesity effects of an antioxidant-rich extract of Spinaciaoleracea (NAOE) and aerobic exercise (AE) in rats fed with high fat diet (HFD).


Rats received NAOE (200 and 400 mg/kg), the standard drug orlistat (10 mg/kg), AE and NAOEAE (NAOE 400 mg/kg + AE) daily with HFD for 21 d.


Orlistat, NAOE and NAOEAE treatments to HFD-fed rats significantly reduced the HFD-elevated food intake, weight gain, pancreatic lipase activity and lipid peroxidation, and successfully restored the HFD-skewed lipid profile and antioxidant levels.


It may be concluded that NAOE exhibited a promising anti-hyperlipidemic effect by its inhibitory action on pancreatic lipase. The combination treatment NAOEAE produced the best results indicating the essential role of exercise along with consumption of antioxidant-rich foods in maintaining a normal lipid profile and controlling obesity.


Spinaciaoleracea extract; aerobic exercise; high fat diet; lipid profile; pancreatic lipase

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