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Cancer Med. 2018 Oct;7(10):5205-5216. doi: 10.1002/cam4.1786. Epub 2018 Sep 30.

The oncogenic roles of nuclear receptor coactivator 1 in human esophageal carcinoma.

Wang L1,2, Li W2, Li K2, Guo Y3, Liu D4, Yao Z1,2, Lin X1,2, Li S5, Jiang Z2, Liu Q6, Jiang Y1, Zhang B2,7, Chen L1, Zhou F8, Ren H2, Lin D9, Zhang D10, Yeung SJ11, Zhang H1,2,12,13.

Author information

1
Department of Immunotherapy and Gastrointestinal Oncology, Affiliated Cancer Hospital of Shantou University Medical College, Shantou, Guangdong, China.
2
Cancer Research Centre, Shantou University Medical College, Shantou, Guangdong, China.
3
Endoscopy Centre, Affiliated Cancer Hospital of Shantou University Medical College, Shantou, Guangdong, China.
4
Department of Thoracic Surgery, Affiliated Cancer Hospital of Shantou University Medical College, Shantou, Guangdong, China.
5
Department of Thoracic Surgery, Second Affiliated Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
6
Department of Pathology, The First People's Hospital of Foshan, Foshan, Guangdong, China.
7
Department of Science and Education, Affiliated Cancer Hospital of Shantou University Medical College, Shantou, Guangdong, China.
8
Department of Pathology, Anyang Tumour Hospital, Anyang, Henan, China.
9
Department of Breast Oncology, Affiliated Cancer Hospital of Shantou University Medical College, Shantou, Guangdong, China.
10
Department of Bio-Medical Sciences, Philadelphia College of Osteopathic Medicine, Philadelphia, Pennsylvania.
11
Department of Emergency Medicine, Department of Endocrine Neoplasia and Hormonal Disorders, The University of Texas MD Anderson Cancer Center, Houston, Texas.
12
Institute of Precision Cancer Medicine and Pathology and Department of Pathology, Jinan University Medical College, Guangzhou, China.
13
Tumor Tissue Bank, Affiliated Cancer Hospital of Shantou University Medical College, Shantou, Guangdong, China.

Erratum in

Abstract

Nuclear receptor coactivator 1 (NCOA1) plays crucial roles in the regulation of gene expression mediated by a wide spectrum of steroid receptors such as androgen receptor (AR), estrogen receptor α (ER α), and estrogen receptor β (ER β). Therefore, dysregulations of NCOA1 have been found in a variety of cancer types. However, the clinical relevance and the functional roles of NCOA1 in human esophageal squamous cell carcinoma (ESCC) are less known. We found in this study that elevated levels of NCOA1 protein and/or mRNA as well as amplification of the NCOA1 gene occur in human ESCC. Elevated levels of NCOA1 due to these dysregulations were not only associated with more aggressive clinic-pathologic parameters but also poorer survival. Results from multiple cohorts of ESCC patients strongly suggest that the levels of NCOA1 could serve as an independent predictor of overall survival. In addition, silencing NCOA1 in ESCC cells remarkably decreased proliferation, migration, and invasion. These findings not only indicate that NCOA1 plays important roles in human ESCC but the levels of NCOA1 also could serve as a potential prognostic biomarker of ESCC and targeting NCOA1 could be an efficacious strategy in ESCC treatment.

KEYWORDS:

SRC-1; coregulator; esophageal carcinoma; invasiveness; migration; proliferation; sex steroid receptor signaling

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