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Cell. 2018 Oct 18;175(3):736-750.e30. doi: 10.1016/j.cell.2018.08.066. Epub 2018 Sep 27.

A Map-like Micro-Organization of Grid Cells in the Medial Entorhinal Cortex.

Author information

1
Princeton Neuroscience Institute, Princeton University, Princeton, NJ 08544, USA; Bezos Center for Neural Circuit Dynamics, Princeton University, NJ 08544, USA. Electronic address: guyi.thu@gmail.com.
2
Princeton Neuroscience Institute, Princeton University, Princeton, NJ 08544, USA; Bezos Center for Neural Circuit Dynamics, Princeton University, NJ 08544, USA.
3
Center for Learning and Memory, University of Texas at Austin, Austin, TX 78712, USA; Department of Neuroscience, University of Texas at Austin, Austin, TX 78712, USA.
4
Princeton Neuroscience Institute, Princeton University, Princeton, NJ 08544, USA; Bezos Center for Neural Circuit Dynamics, Princeton University, NJ 08544, USA. Electronic address: dwtank@princeton.edu.

Abstract

How the topography of neural circuits relates to their function remains unclear. Although topographic maps exist for sensory and motor variables, they are rarely observed for cognitive variables. Using calcium imaging during virtual navigation, we investigated the relationship between the anatomical organization and functional properties of grid cells, which represent a cognitive code for location during navigation. We found a substantial degree of grid cell micro-organization in mouse medial entorhinal cortex: grid cells and modules all clustered anatomically. Within a module, the layout of grid cells was a noisy two-dimensional lattice in which the anatomical distribution of grid cells largely matched their spatial tuning phases. This micro-arrangement of phases demonstrates the existence of a topographical map encoding a cognitive variable in rodents. It contributes to a foundation for evaluating circuit models of the grid cell network and is consistent with continuous attractor models as the mechanism of grid formation.

KEYWORDS:

calcium imaging; continuous attractor network models; grid cell; grid module; grid phase; medial entorhinal cortex; microprism; pyramidal cell; stellate cell; virtual reality

PMID:
30270041
PMCID:
PMC6591153
[Available on 2019-10-18]
DOI:
10.1016/j.cell.2018.08.066
[Indexed for MEDLINE]

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