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J Cardiothorac Vasc Anesth. 2018 Aug 29. pii: S1053-0770(18)30857-7. doi: 10.1053/j.jvca.2018.08.203. [Epub ahead of print]

Shifts of Transfusion Demand in Cardiac Surgery After Implementation of Rotational Thromboelastometry-Guided Transfusion Protocols: Analysis of the HEROES-CS (HEmostasis Registry of patiEntS in Cardiac Surgery) Observational, Prospective Open Cohort Database.

Author information

1
Department of Anaesthesiology and Pain Treatment, Maastricht University Medical Center, Maastricht, the Netherlands; Laboratory for Clinical Thrombosis and Haemostasis, Department of Internal Medicine, Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, Maastricht, the Netherlands. Electronic address: gerhardus.kuiper@one-mail.on.ca.
2
Central Diagnostic Laboratory, Cluster for Haemostasis and Transfusion, Maastricht University Medical Center, Maastricht, the Netherlands.
3
Department of Intensive Care Medicine, Maastricht University Medical Center, Maastricht, the Netherlands.
4
Department of Cardiothoracic Surgery, Maastricht University Medical Center, Maastricht, the Netherlands.
5
Department of Internal Medicine, Maastricht University Medical Center, Maastricht, the Netherlands; Laboratory for Clinical Thrombosis and Haemostasis, Department of Internal Medicine, Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, Maastricht, the Netherlands.
6
Department of Anaesthesiology and Pain Treatment, Maastricht University Medical Center, Maastricht, the Netherlands.

Abstract

OBJECTIVES:

Rotational thromboelastometry (ROTEM)-guided transfusion algorithms in cardiac surgery have been proven to be successful in reducing blood loss in randomized controlled trials. Using an institutional hemostasis registry of patients in cardiac surgery (HEROES-CS), the authors hypothesized that the use of ROTEM-guided transfusion algorithms would save blood products and overall costs in cardiac surgery in every day practice.

DESIGN:

Observational, prospective open cohort database.

SETTING:

Single-center academic hospital.

PARTICIPANTS:

Cardiac surgery patients.

INTERVENTIONS:

Implementation of ROTEM-guided bleeding management.

MEASUREMENTS AND MAIN RESULTS:

A classical-guided algorithm and a ROTEM-guided algorithm were used for patient blood management in 2 cohorts. Primary outcome was the use and amount of blood products and hemostatic medication. Secondary outcomes were amount of rethoracotomies, length of stay, and 30-day mortality. Finally, costs and savings were calculated. The classical-guided cohort comprised 204 patients, and ROTEM-guided cohort comprised 151 patients. Baseline characteristics showed excellent similarities after propensity score matching of 202 patients. Blood loss was lower after ROTEM guidance (p < 0.001). Absolute risk reduction was 17% for red blood cells (p = 0.024), 12% for fresh frozen plasma (p = 0.019), and 4% for thrombocyte concentrates (p = 0.582). More tranexamic acid was given, but notmore fibrinogen concentrate, whiledesmopressin was given less often. Hospital length of stay was reduced by an overall median of 2 and a mean of 4days (p < 0.001). Mortality and rethoracotomy rates were not affected. Potential savings were about €4,800 ($5,630) per patient.

CONCLUSIONS:

Implementation of a ROTEM-guided transfusion algorithm in cardiac surgery patients reduced the use of blood products and hemostatic medication, hereby saving costs. Reductions in mortality and rethoracotomy rates could not be found.

KEYWORDS:

algorithm; bleeding; cardiac surgery; mortality; thromboelastometry; transfusion

PMID:
30269889
DOI:
10.1053/j.jvca.2018.08.203

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