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Pediatr Exerc Sci. 2019 Feb 1;31(1):28-36. doi: 10.1123/pes.2018-0058. Epub 2018 Sep 30.

Cardiac Biomarker Release After Exercise in Healthy Children and Adolescents: A Systematic Review and Meta-Analysis.

Author information

1
National Institute of Physical Education of Catalonia.
2
University of Zaragoza.
3
Liverpool John Moores University.
4
Macao Polytechnic Institute.
5
Universidad Autónoma de Nuevo León.
6
University of Lleida.

Abstract

PURPOSE:

The authors evaluated the impact of acute exercise and 24-hour recovery on serum concentration of cardiac troponins T and I (cTnT and cTnI) and N-terminal fragment of the prohormone brain natriuretic peptide (NT-proBNP) in healthy children and adolescents. The authors also determined the proportion of participants exceeding the upper reference limits and acute myocardial infarction cutoff for each assay.

METHOD:

Web of Science, SPORTDiscus, MEDLINE, ScienceDirect, and Scopus databases were systematically searched up to November 2017. Studies were screened and quality-assessed; the data was systematically extracted and analyzed.

RESULTS:

From 751 studies initially identified, 14 met the inclusion criteria for data extraction. All 3 biomarkers were increased significantly after exercise. A decrease from postexercise to 24 hours was noted in cTnT and cTnI, although this decrease was only statistically significant for cTnT. The upper reference limit was exceeded by 76% of participants for cTnT, a 51% for cTnI, and a 13% for NT-proBNP. Furthermore, the cutoff value for acute myocardial infarction was exceeded by 39% for cTnT and a 11% for cTnI. Postexercise peak values of cTnT were associated with duration and intensity (Q(3) = 28.3, P < .001) while NT-proBNP peak values were associated with duration (Q(2) = 11.9, P = .003).

CONCLUSION:

Exercise results in the appearance of elevated levels of cTnT, cTnI, and NT-proBNP in children and adolescents. Postexercise elevations of cTnT and NT-proBNP are associated with exercise duration and intensity.

KEYWORDS:

NT-proBNP; cTnI; cTnT; sport medicine

PMID:
30269651
DOI:
10.1123/pes.2018-0058
[Indexed for MEDLINE]

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