Format

Send to

Choose Destination
Aging Male. 2018 Sep 29:1-10. doi: 10.1080/13685538.2018.1498079. [Epub ahead of print]

Lycium chinense Mill improves hypogonadism via anti-oxidative stress and anti-apoptotic effect in old aged rat model.

Author information

1
a Department of Urology , Kangdong Sacred Heart Hospital, Hallym University College of Medicine , Seoul , Korea.
2
b Department of Urology , College of Medicine, The Catholic University of Korea , Seoul , Korea.
3
c Catholic Integrative Medicine Research Institute, College of Medicine, The Catholic University of Korea , Seoul , Korea.
4
d Biomix Inc , Goyang , Korea.

Abstract

PURPOSE:

To evaluate the pharmacological effects of goji berry (Lycium chinense P. Mill) in an animal model of late-onset hypogonadism (LOH).

MATERIALS AND METHODS:

Thirty 18-month-old male Sprague-Dawley (SD) rats were used as the LOH aged rat model. Rats were divided into five groups: a control group (n = 6), low concentration goji berry extract group (150 mg/kg/day) (n = 6), high concentration goji berry extract group (300 mg/kg/day) (n = 6), low concentration goji berry complex extract group (150 mg/kg/day) (n = 6), and high goji berry complex concentration extract group (300 mg/kg/day) (n = 6). After six weeks of treatment, sperm counts and motility, serum testosterone level, androgen receptor (AR) expression, oxidative stress marker, and apoptotic factors were examined.

RESULTS:

Goji berry extracts increased testosterone level to 2.07 ± 0.06 pmol/L in the goji berry 150 mg/kg group, 2.39 ± 0.08 pmol/L in the goji berry 300 mg/kg group, 2.97 ± 0.03 pmol/L in the goji berry complex 150 mg/kg group, and 3.34 ± 0.04 pmol/L in the goji berry complex 300 mg/kg group compared to 1.86 ± 0.03 pmol/L in the control group, respectively (p < .05). AR expressions were increased in testis tissue significantly but were not significant in prostate tissue.

CONCLUSIONS:

Goji berry might improve LOH by reversing testicular dysfunction via an anti-oxidative stress mechanism without inducing prostate disease.

KEYWORDS:

Antioxidant; animal model; goji berry; late-onset hypogonadism; testosterone

Supplemental Content

Full text links

Icon for Taylor & Francis
Loading ...
Support Center