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Oral Dis. 2018 Sep 30. doi: 10.1111/odi.12984. [Epub ahead of print]

t(6;9)(MYB-NFIB) in head and neck adenoid cystic carcinoma: A systematic review with meta-analysis.

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Department of Oral Surgery and Pathology, School of Dentistry Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Department of Oral Pathology, School of Dentistry Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
School of Medical Sciences Department of Pathology, University of Campinas, Campinas, Brazil.
Department of Oral Diagnosis, Piracicaba Dental School University of Campinas, Piracicaba, Brazil.
Department of Paediatric Dentistry and Orthodontics, School of Dentistry Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.


The presence of a translocation involving MYB and NFIB genes have been described in adenoid cystic carcinoma (AdCC) from different anatomical regions. However, the exact frequency of this genetic event and its prognostic impact for patient survival remain obscure. The aim of this study was to carry out a systematic review to address the prevalence and the prognostic potential of t(6;9)(MYB-NFIB) in head and neck AdCC. Quantitative analysis was done to determine the prevalence of the translocation. A total of 1107 articles were initially retrieved with 36 remaining for data extraction. The prevalence of t(6;9)(MYB-NFIB) varied significantly (16% to 100%), especially due to methodological heterogeneity among studies. A total of 11 studies attempted to determine the prognostic importance of the translocation, but no study found any significant association with survival rates; only three studies observed a significant association with age, sex, tumour location and the presence of recurrences and metastases. The prevalence of t(6;9)(MYB-NFIB) in head and neck AdCC varies according to the laboratorial methods used, and the best evidence available demonstrates that t(6;9)(MYB-NFIB) does not seem to be a prognostic determinant. This article is protected by copyright. All rights reserved.


MYB ; NFIB ; 9); Adenoid cystic carcinoma; head and neck cancer; salivary gland neoplasm; t(6


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