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Free Radic Biol Med. 2019 Mar;133:130-143. doi: 10.1016/j.freeradbiomed.2018.09.043. Epub 2018 Sep 28.

The development of the concept of ferroptosis.

Author information

1
Department of Biological Sciences, Columbia University, New York, NY, USA.
2
Department of Biological Sciences, Columbia University, New York, NY, USA; Department of Chemistry, Columbia University, New York, NY, USA. Electronic address: bstockwell@columbia.edu.

Abstract

The term ferroptosis was coined in 2012 to describe an iron-dependent regulated form of cell death caused by the accumulation of lipid-based reactive oxygen species; this type of cell death was found to have molecular characteristics distinct from other forms of regulated cell death. Features of ferroptosis have been observed periodically over the last several decades, but these molecular features were not recognized as evidence of a distinct form of cell death until recently. Here, we describe the history of observations consistent with the current definition of ferroptosis, as well as the advances that contributed to the emergence of the concept of ferroptosis. We also discuss recent implications and applications of manipulations of the ferroptotic death pathway.

KEYWORDS:

Cell death; Chemical biology; Cysteine; Ferroptosis; Iron; Lipid peroxidation; Metabolism

PMID:
30268886
PMCID:
PMC6368883
[Available on 2020-03-01]
DOI:
10.1016/j.freeradbiomed.2018.09.043

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