Format

Send to

Choose Destination
BMC Infect Dis. 2018 Sep 29;18(1):493. doi: 10.1186/s12879-018-3405-1.

Carbapenem susceptibilities of Gram-negative pathogens in intra-abdominal and urinary tract infections: updated report of SMART 2015 in China.

Author information

1
Division of Microbiology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, No. 1 Shuaifuyuan, Wangfujing Street, Beijing, 100730, China.
2
Department of Microbiology, The First Affiliated Hospital of Zhejiang University, Hangzhou, 310003, China.
3
Department of Infectious Diseases, SirRunRun Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, 310016, China.
4
Infection Control Center, Xiangya Hospital, Central South University, Changsha, 410008, China.
5
Microbiology Laboratory, Jilin Province People's Hospital, Changchun, 130021, China.
6
The Fourth Hospital of Harbin Medical University, No. 37 Yiyuan Road, Nangang District, Harbin, China.
7
Division of Microbiology, Haikou People's Hospital, Haikou, 570208, China.
8
Department of Laboratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
9
Division of Microbiology, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, 200025, China.
10
Nanjing General Hospital, No. 305 Zhongshan Dong Road, Nanjing, China.
11
Department of Laboratory Medicine, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, 250021, China.
12
Division of Microbiology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510080, China.
13
Zhongshan Hospital Affiliated to Fudan University, No. 180 Fenglin Road, Shanghai, 200032, China.
14
Beijing Chao-yang Hospital, 8 Gongren Tiyuchang Nanlu, Chaoyang District, Beijing, 100020, China.
15
Division of Microbiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.
16
Clinical laboratory, The Second Affiliated Hospital of Nanchang University, Nanchang, 330006, China.
17
First Affiliated Hospital of Kunming Medical University, No. 295 Xichang Road, Kunming, 650032, China.
18
Division of Microbiology, International Health Management Associates, Schaumburg, IL, 60173-3817, USA.
19
Division of Microbiology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, No. 1 Shuaifuyuan, Wangfujing Street, Beijing, 100730, China. yangqiwen81@163.com.
20
Division of Microbiology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, No. 1 Shuaifuyuan, Wangfujing Street, Beijing, 100730, China. xycpumch@139.com.

Abstract

BACKGROUND:

To evaluate the susceptibility rates of aerobic and facultative Gram-negative bacterial isolates from Chinese intra-abdominal infections (IAI) and urinary tract infections (UTI) focusing on carbapenems and comparing their effectiveness between 2014 and 2015.

METHODS:

A total of 2318 strains in 2015 (1483 from IAI and 835 from UTI) and 2374 strains in 2014 (1438 from IAI and 936 from UTI) were included in the analysis. Antimicrobial susceptibilities were determined at a central laboratory using CLSI broth microdilution and interpretive standards. Hospital acquired (HA) IAI and UTI were defined as isolates sampled > 48 h and community acquired (CA) as isolates sampled < 48 h after admission.

RESULTS:

The main species derived from IAI and UTI in 2015 were Escherichia coli (50.86%) and Klebsiella pneumoniae (19.20%). Susceptibilities of Escherichia coli IAI and UTI strains to imipenem (IPM) and ertapenem (ETP) were > 90% in 2014 and 2015, while the susceptibilities to IPM and ETP of Klebsiella pneumoniae IAI strains were >  80% in 2014 but dropped to ≤80% in 2015 for UTI strains. Susceptibilities of IAI Enterobacteriaceae strains to IPM and ETP in 2015 were lowest in the colon and abscesses, and Enterobacteriaceae susceptibilities of UTI and IAI isolates to IPM and ETP were lowest in medical, pediatric and surgery intensive care units (ICUs) in 2015.

CONCLUSIONS:

IPM and ETP were effective in vitro against Enterobacteriaceae isolated from IAIs and UTIs in 2014 and 2015, but susceptibility to carbapenems in UTIs markedly decreased in 2015.

KEYWORDS:

Carbapenem; ertapenem; Enterobacteriaceae; Imipenem; Intra-abdominal infection; Urinary tract infection

PMID:
30268102
PMCID:
PMC6162895
DOI:
10.1186/s12879-018-3405-1
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for BioMed Central Icon for PubMed Central
Loading ...
Support Center