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Protein Sci. 2018 Dec;27(12):1984-2009. doi: 10.1002/pro.3519.

The molecular details of cytokine signaling via the JAK/STAT pathway.

Author information

1
Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, 3052, Victoria, Australia.
2
Department of Medical Biology, The University of Melbourne, Royal Parade, Parkville, 3050, Victoria, Australia.

Abstract

More than 50 cytokines signal via the JAK/STAT pathway to orchestrate hematopoiesis, induce inflammation and control the immune response. Cytokines are secreted glycoproteins that act as intercellular messengers, inducing proliferation, differentiation, growth, or apoptosis of their target cells. They act by binding to specific receptors on the surface of target cells and switching on a phosphotyrosine-based intracellular signaling cascade initiated by kinases then propagated and effected by SH2 domain-containing transcription factors. As cytokine signaling is proliferative and often inflammatory, it is tightly regulated in terms of both amplitude and duration. Here we review molecular details of the cytokine-induced signaling cascade and describe the architectures of the proteins involved, including the receptors, kinases, and transcription factors that initiate and propagate signaling and the regulatory proteins that control it.

KEYWORDS:

Cytokine Signaling; JAK/STAT; SOCS; cytokine; cytokine receptor; hematopoiesis

PMID:
30267440
PMCID:
PMC6237706
[Available on 2019-12-01]
DOI:
10.1002/pro.3519
[Indexed for MEDLINE]

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