Format

Send to

Choose Destination
J Perinatol. 2019 Jan;39(1):48-53. doi: 10.1038/s41372-018-0236-2. Epub 2018 Sep 28.

Early hypoxemia burden is strongly associated with severe intracranial hemorrhage in preterm infants.

Author information

1
Division of Newborn Medicine, Department of Pediatrics, Washington University School of Medicine, St. Louis, MO, USA. vesoulis_z@wustl.edu.
2
Division of Newborn Medicine, Department of Pediatrics, Washington University School of Medicine, St. Louis, MO, USA.
3
Department of Medicine, University of Virginia, Charlottesville, VA, USA.
4
Department of Pediatrics, Columbia University, New York, NY, USA.
5
Department of Pediatrics, University of Virginia, Charlottesville, VA, USA.

Abstract

OBJECTIVES:

The objective of this study was to define the association between the burden of severe hypoxemia (SpO2 ≤70%) in the first week of life and development of severe ICH (grade III/IV) in preterm infants.

STUDY DESIGN:

Infants born at <32 weeks or weighing <1500 g underwent prospective SpO2 recording from birth through 7 days. Severe hypoxemia burden was calculated as the percentage of the error-corrected recording where SpO2 ≤70%. Binary logistic regression was used to model the relationship between hypoxemia burden and severe ICH.

RESULTS:

A total of 163.3 million valid SpO2 data points were collected from 645 infants with mean EGA = 27.7 ± 2.6 weeks, BW = 1005 ± 291 g; 38/645 (6%) developed severe ICH. There was a greater mean hypoxemia burden for infants with severe ICH (3%) compared to those without (0.1%) and remained significant when controlling for multiple confounding factors.

CONCLUSION:

The severe hypoxemia burden in the first week of life is strongly associated with severe ICH.

Supplemental Content

Full text links

Icon for Nature Publishing Group Icon for PubMed Central
Loading ...
Support Center