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J Agric Food Chem. 2018 Oct 31;66(43):11426-11431. doi: 10.1021/acs.jafc.8b02505. Epub 2018 Oct 18.

Role for Transferrin in Triggering Apoptosis in Helicoverpa armigera Cells Treated with 2-Tridecanone.

Abstract

2-Tridecanone, a plant allelochemical present in a large range of tomato species ( Lycopersicon hirsutum f. glabratum), can induce the expression of Helicoverpa armigera transferrin ( HaTrf), which is necessary for insect growth and development. To gain further insight into the mechanism of HaTrf in response to 2-tridecanone, we measured the iron and H2O2 levels in the hemolymph during exposure to 2-tridecanone and then explored the effect of transferrin downregulation in a H. armigera fat body cell line exposed to 2-tridecanone. We found that the reduction of HaTrf levels via RNA interference caused rapid apoptotic cell death during exposure to 2-tridecanone. There have been no reports about transferrin genes related to apoptosis induced by plant allelochemicals. Our results indicate that HaTrf mediates the inhibition of apoptotic cell death during exposure to 2-tridecanone and provides insight into the importance of transferrin in the interaction between plants and insects.

KEYWORDS:

2-tridecanone; Helicoverpa armigera; RNA interference; apoptosis; transferrin

PMID:
30265533
DOI:
10.1021/acs.jafc.8b02505
[Indexed for MEDLINE]

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