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J Postgrad Med. 2018 Oct-Dec;64(4):232-236. doi: 10.4103/jpgm.JPGM_706_17.

Primary osteogenic sarcoma of the skull: Report of two cases with review of literature.

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Department of Pathology, Institute of Human Behaviour and Allied Sciences, New Delhi, India.
Department of Neurosurgery, Guru Teg Bahadur Hospital, New Delhi, India.


Primary calvarial (excluding jaw) osteosarcoma is rare. We report two cases highlighting their unusual presentation and histopathologic variability - a 30-year-old female who presented with progressively increasing headache and a rapidly growing frontal swelling and a 16-year-old girl who had a rapidly growing mass in the left frontoparietal region which had recurred thrice but was otherwise asymptomatic. The lesions were osteolytic on neuroimaging and histopathological examination confirmed osteosarcoma. These two unusual cases are discussed along with a brief review of literature.


Craniofacial; primary osteosarcoma; skull

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