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Curr Protein Pept Sci. 2019;20(1):82-91. doi: 10.2174/1389203719666180928105632.

Targeting PD-L1 Protein: Translation, Modification and Transport.

Author information

1
Provincial University Key Laboratory of Cellular Stress Response and Metabolic Regulation, College of Life Sciences, Fujian Normal University, Fuzhou 350117, China.
2
Cancer Centre, Faculty of Health Sciences, University of Macau, Avenida de Universidade, Taipa, Macau SAR, China.
3
School of Life Sciences, Nantong University, Nantong, Jiangsu, China.

Abstract

Programmed death ligand 1 (PD-L1) is a cell membrane protein that binds to programmed cell death protein 1 (PD-1) on the effector T cells and transduces immunosuppressive signals. It is now clear that the expression of the PD-L1 protein on the tumor cell surface is critical for tumor cells to escape immunosuppression. At present, more attention is focused on the transcriptional regulation of PDL1 mRNA. However, PD-L1 protein is the functional unit involved in immunotherapy response. It is essential to deeply understand how this membrane protein is regulated post-transcriptionally in tumors and immune cells. In this review, we summarize the recent progress on the translation, modification and transport of PD-L1 protein.

KEYWORDS:

Programmed death ligand 1 (PD-L1); immunotherapy; modification; programmed cell death protein 1 (PD-1); translation; transport.

[Indexed for MEDLINE]

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