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Arch Pharm Res. 2018 Nov;41(11):1082-1091. doi: 10.1007/s12272-018-1080-9. Epub 2018 Sep 27.

Chemical constituents of the roots of Codonopsis lanceolata.

Author information

1
Department of Life & Nanopharmaceutical Sciences, Graduate School, Kyung Hee University, Seoul, 02447, Republic of Korea.
2
College of Pharmacy, Kyung Hee University, Seoul, 02447, Republic of Korea.
3
Department of Life & Nanopharmaceutical Sciences, Graduate School, Kyung Hee University, Seoul, 02447, Republic of Korea. dsjang@khu.ac.kr.
4
College of Pharmacy, Kyung Hee University, Seoul, 02447, Republic of Korea. dsjang@khu.ac.kr.

Abstract

A new phenylpropanoid (1), a new alkaloid (11), and a new natural polyacetylene (17), together with nine phenolic compounds (2-10), five alkaloids (12-16), three polyacetylenes (18-20), three triterpenoidal saponins (21-23), one phenylethanoid glycoside (24), and three hexyl glycosides (25-27) with previous known structures, were isolated from the roots of Codonopsis lanceolata. All of the isolates 1-27 were evaluated for their inhibitory effects on LPS-induced nitric oxide (NO) production in RAW 264.7 macrophages and cell viability in A2780 human ovarian cancer cells. Among the isolates, lancemasides A and B have a significant inhibitory effect on the production of NO in RAW264.7 cells (IC50 values < 50 μM). In A2780 cells, lancemaside A exhibited the most potent inhibitory effect on cell viability. This is the first report on the pharmacological activities of lancemaside B (22).

KEYWORDS:

Campanulaceae; Codonopsis lanceolate; Lancemasides; Nitric oxide; Ovarian cancer cells

PMID:
30264325
DOI:
10.1007/s12272-018-1080-9
[Indexed for MEDLINE]

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