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Chem Commun (Camb). 2018 Oct 11;54(82):11606-11609. doi: 10.1039/c8cc06838k.

Analysis and engineering of substrate shuttling by the acyl carrier protein (ACP) in fatty acid synthases (FASs).

Author information

1
Department of Theoretical Biophysics, Max Planck Institute of Biophysics, Max-von-Laue-Stra├če 3, 60438 Frankfurt am Main, Germany. gerhard.hummer@biophys.mpg.de.

Abstract

Perturbations of domain-domain interactions impact the function of type I fatty acid synthases. We identify interface point mutations that modulate fatty acid chain lengths, and explain their effect in changes of domain-domain binding energetics. Engineering of similar interfaces in related megasynthases may be exploited for custom synthesis of natural products.

PMID:
30264077
DOI:
10.1039/c8cc06838k
[Indexed for MEDLINE]

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