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Food Sci Biotechnol. 2017 Sep 8;26(5):1185-1190. doi: 10.1007/s10068-017-0176-1. eCollection 2017.

Monitoring of the amphetamine-like substances in dietary supplements by LC-PDA and LC-MS/MS.

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New Hazardous Substances Team, Department of Food Safety Evaluation, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety, Cheongju, Chungbuk, 28159 Korea.


Recently, amphetamine-like substances derived from the β-phenylethylamine core structure have been detected in dietary supplements. Especially, β-methylphenylethylamine (BMPEA), an amphetamine isomer, has been found in dietary supplements labeled as containing Acacia rigidula. The U. S. Food and Drug Administration determined that BMPEA is not naturally present in food and does not meet the statutory definition of a dietary ingredient. In addition, BMPEA has been classified as a psychotropic drug in South Korea and a doping substance by the World Anti-Doping Agency. The aim of this study was to determine whether dietary supplements contained amphetamine and amphetamine-like substance, including β-phenylethylamine (β-PEA) and BMPEA using LC-PDA and LC-MS/MS. In 10 of 110 samples, illegally added compounds were detected in the following ranges; β-PEA 1.4-122.0 mg/g and BMPEA 4.7-37.6 mg/g. This study will contribute to enhancement of food safety in the South Korea.


Acacia rigidula; Amphetamine; BMPEA; Illegal compound; β-Methylphenylethylamine

Conflict of interest statement

Compliance with ethical standardsThe authors declare no conflict of interest.

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