Format

Send to

Choose Destination
Presse Med. 2018 Sep;47(9):757-763. doi: 10.1016/j.lpm.2018.08.009. Epub 2018 Sep 24.

Is hypertriglyceridemia atherogenic?

Author information

1
Montpellier University Hospital, UFR de Médecine, Université Montpellier 1, Department of Cardiology, 371, avenue du Doyen-Gaston-Giraud, 34295 Montpellier cedex 5, France; Université de Montpellier, PhyMedExp, Inserm, CNRS, 34000 Montpellier, France. Electronic address: francois.roubille@gmail.com.
2
Université de Montpellier, PhyMedExp, Inserm, CNRS, 34000 Montpellier, France; Montpellier University Hospital, Department of Endocrinology-Diabetes-Nutrition, 34295 Montpellier cedex 5, France.
3
Montpellier University Hospital, UFR de Médecine, Université Montpellier 1, Department of Cardiology, 371, avenue du Doyen-Gaston-Giraud, 34295 Montpellier cedex 5, France; Université de Montpellier, PhyMedExp, Inserm, CNRS, 34000 Montpellier, France.
4
Montpellier University Hospital, UFR de Médecine, Université Montpellier 1, Department of Cardiology, 371, avenue du Doyen-Gaston-Giraud, 34295 Montpellier cedex 5, France.
5
Université de Montpellier, PhyMedExp, Inserm, CNRS, 34000 Montpellier, France.

Abstract

ASCVD reduction is based on LDL reduction, especially by statins. Highly elevated TG could be harmful, especially because of the risk of pancreatitis. Elevation of TG is mainly due to metabolic disorders and diabetes, alcohol intake and overweight. Genetic factors have been clearly identified in the most severe cases. TG have been generally considered as bystanders for cardiovascular diseases (CVD). Both biological and basic research provide strong data suggesting that TG-rich lipoproteins could be involved in the pathophysiology of CVD. Recent epidemiological and genetics studies strongly corroborate the causal role of TG in CVD. This paves the way for new approaches in the management of patients both for primary and secondary prevention.

PMID:
30262206
DOI:
10.1016/j.lpm.2018.08.009
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center