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Diagn Interv Imaging. 2018 Sep 24. pii: S2211-5684(18)30221-3. doi: 10.1016/j.diii.2018.08.014. [Epub ahead of print]

Distribution of left ventricular trabeculation across age and gender in 140 healthy Caucasian subjects on MR imaging.

Author information

1
UMR CNRS 7339, Aix-Marseille University, 13385 Marseille cedex 05, France; Centre de Résonance Magnétique Biologique et Médicale, Hôpital de la Timone, AP-HM, 13385 Marseille cedex 05, France. Electronic address: zakarya.bentatou@etu.univ-amu.fr.
2
Department of Radiology, CHU de Grenoble, 38043 Grenoble cedex 9, France.
3
Department of Cardiology, Aix-Marseille Université, Hôpital de la Timone, AP-HM, 13385 Marseille cedex 05, France.
4
UMR CNRS 7339, Aix-Marseille University, 13385 Marseille cedex 05, France.
5
UMR CNRS 7339, Aix-Marseille University, 13385 Marseille cedex 05, France; Centre de Résonance Magnétique Biologique et Médicale, Hôpital de la Timone, AP-HM, 13385 Marseille cedex 05, France.
6
Le2i, University de Bourgogne-Franche Comté, 21000 Dijon, France.
7
Le2i, University de Bourgogne-Franche Comté, 21000 Dijon, France; MRI Department, University Hospital of Dijon, 21000 Dijon, France.
8
Cardiac Imaging Unit, Department of Radiology, hôpital universitaire de Rouen, 76031 Rouen, France.
9
Department of Cardiology, Aix-Marseille Université, Hôpital de la Timone, AP-HM, 13385 Marseille cedex 05, France; IRD, IHU-Méditerranée Infection, université d'Aix Marseille, MEPHI, AP-HM, 13385 Marseille cedex 05, France.

Abstract

PURPOSE:

The purpose of this study was to quantify the distribution of trabeculated (T) and compact (C) left ventricular (LV) myocardium masses in a healthy Caucasian population against age, gender and LV parameters, and to provide normal values for T, C and T/C.

MATERIALS AND METHODS:

One hundred and forty healthy subjects were prospectively recruited and underwent cardiac MRI at 1.5T with a stack of short-axis cine sequences covering the entire LV. End-diastolic volume (EDV), C and T masses were quantified using a semi-automatic method. Ejection fraction (EF) and T/C ratio were computed.

RESULTS:

We included 70 men and 70 women with a mean age of 44±14 (SD) years (range: 20-69 years). The mean EF was 63.7±6.3 (SD) % (range: 50.7-82.0%), the mean EDV was 75.9±16.2 (SD) mL/m2 (range: 36.4-112.2mL/m2), the mean C mass was 53.9±11.2 (SD) g/m2 (range: 26.5-93.4g/m2) and the mean T mass was 4.9±2.4 (SD) g/m2 (range: 1.1-11.4g/m2). The T/C ratio was 9.2±4.5% (range: 2.0-29.4%). Multivariate ANOVA test showed that the compact mass was influenced by EDV (P<0.0001), EF (P=0.001) and gender (P<0.0001), and the trabeculated mass depended on EDV (P<0.0001), gender (P=0.002) and age (P<0.0001), while the T/C ratio was only influenced by age (P=0.0003). Spearman test showed a correlation between EDV and C (r=0.60; P<0.0001),T (r=0.46; P<0.0001) and T/C ratio (r=0.26; P=0.0023).T and T/C ratio correlated with EF (r=-0.18, P=0.0373; r=-0.18, P=0.0321, respectively).

CONCLUSION:

While the compact and trabeculated myocardium masses appear to relate separately to the cardiac function, age and gender, their ratio T/C appears to only decrease with age. Furthermore, we propose here normal values for T, C and T/C in a cohort of healthy Caucasians subjects.

KEYWORDS:

Cardiac magnetic resonance imaging (CMR); Left ventricular function; Left ventricular remodeling; Myocardium

PMID:
30262171
DOI:
10.1016/j.diii.2018.08.014

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