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PLoS One. 2018 Sep 27;13(9):e0203868. doi: 10.1371/journal.pone.0203868. eCollection 2018.

Association of serum lutein and zeaxanthin with quantitative measures of retinal vascular parameters.

Author information

1
Department of Ophthalmology and Visual Sciences, Khoo Teck Puat Hospital, Singapore, Republic of Singapore.
2
Singapore Eye Research Institute, Singapore National Eye Center, Singapore, Republic of Singapore.
3
Ophthalmology and Visual Sciences Academic Clinical Programme, Duke-NUS Graduate Medical School, National University of Singapore, Singapore, Republic of Singapore.
4
Department of Ophthalmology and Visual Sciences, the Chinese University of Hong Kong, Shatin, Hong Kong, The People's Republic of China.

Abstract

To evaluate the association between serum carotenoids and quantitative measures of retinal vasculature in elderly Singapore Chinese subjects. The following details were collected in 128 healthy subjects: sociodemographics, lifestyle information, medical and drug history, and anthropometric measurements. Serum concentrations of carotenoids were estimated in fasting venous blood using high performance liquid chromatography. Retinal vascular parameters were quantitatively measured from retinal photographs using a computer-assisted program (Singapore I Vessel Assessment). The mean age of the population was 54.1 years (range 40 to 81 years). In multiple linear regression analysis, per SD decrease in retinal arteriolar caliber [β = 0.045 (0.003 to 0.086), p = 0.036], per SD increase in retinal venular caliber [β = -0.045 (-0.086 to -0.003), p = 0.036] and per SD increase in arteriolar branching angle [β = -0.039 (-0.072 to -0.006), p = 0.021] were associated with decreased serum lutein. Per SD increase in retinal venular tortuosity [β = -0.0075 (-0.0145 to -0.0004), p = 0.039] and per SD increase in arteriolar branching angle (β = -0.0073 [-0.0142 to -0.0059], p = 0.041) were associated with decreased serum zeaxanthin. None of the other carotenoids demonstrated meaningful relationship with quantitative measures of retinal vasculature. Lower levels of lutein and zeaxanthin demonstrated significant relationship with adverse quantitative measures of retinal vasculature in elderly healthy subjects.

Conflict of interest statement

Alexandra Health Private Limited does not alter our adherence to PLOS ONE policies on sharing data and materials.

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