Send to

Choose Destination
Hum Vaccin Immunother. 2018 Sep 27. doi: 10.1080/21645515.2018.1528835. [Epub ahead of print]

HBV vaccine and risk of developing multiple sclerosis: a systematic review and meta-analysis.

Author information

a Department of Public Health and Infectious Diseases , Sapienza University , Rome.
b University of Lisbon.


Hepatitis B virus (HBV) infection is one the most common in the world. Aim of this study is to perform a systematic review on the relationship between HBV vaccination and multiple sclerosis. Research was conducted on Pubmed, ISI Web of Science, and Scopus. Terms "hepatitis b vaccination" and "multiple sclerosis" were used. Meta-analysis and metaregression were performed. 414 papers were found. Seven articles were selected. For the reported crude risk estimates for MS no statistically significant association was observed with pooled OR 1,19 (95%CI: 0,96-1,49). For the adjusted ORs, the pooled odds ratio (OR) was 0, 965 (95%CI: 0,886- 1,051). Meta regression show that year of publication is negatively (β: -0,019; P < 0.001) and NOS score and publishing in Europe are positively associated with O.R. value. Funnel plot showed the presence of publication bias. Results showed that Hepatitis B vaccination is not associated with an increased risk of developing MS.


Hepatitis B; multiple sclerosis; public health; vaccination

Supplemental Content

Full text links

Icon for Taylor & Francis
Loading ...
Support Center