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CPT Pharmacometrics Syst Pharmacol. 2018 Nov;7(11):706-708. doi: 10.1002/psp4.12357. Epub 2018 Oct 23.

Establishing a Multidisciplinary Framework to Study Drug-Drug Interactions of Hormonal Contraceptives: An Invitation to Collaborate.

Author information

1
Center for Pharmacometrics and Systems Pharmacology, Department of Pharmaceutics, College of Pharmacy, University of Florida, Lake Nona (Orlando), Florida, USA.
2
Department of Pharmaceutical Outcomes and Policy, College of Pharmacy, University of Florida, Gainesville, Florida, USA.
3
The Bill & Melinda Gates Foundation, Seattle, Washington, USA.
4
Clinical Pharmacometrics, Bayer AG Pharmaceuticals, Wuppertal, Germany.
5
Bayer AG, Berlin, Germany.
6
Department of Pharmacotherapy, University of North Texas Health Science Center, Fort Worth, Texas, USA.

Abstract

Hormonal contraceptive agents (HCAs) are widely used throughout the world, and women taking HCAs are likely to take other medications. However, little is known about the clinical effect of most drug-drug interactions (DDIs) associated with HCAs. A team of interdisciplinary outcomes and pharmacometric researchers from academia and industry jointly engage in a research project to (i) quantitatively elucidate DDI impacts on unintended pregnancies and breakthrough bleeding, and (ii) establish a DDI-prediction framework to inform optimal use of HCAs.

PMID:
30260082
PMCID:
PMC6263668
DOI:
10.1002/psp4.12357
[Indexed for MEDLINE]
Free PMC Article

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