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Adv Exp Med Biol. 2018;1087:299-308. doi: 10.1007/978-981-13-1426-1_24.

Functional Role of Circular RNA in Regenerative Medicine.

Author information

1
Zhongshan-Xuhui Hospital, Fudan University/Shanghai Clinical Research Center, Chinese Academy of Sciences, Shanghai, China.
2
MetroWest Medical Center, Framingham, MA, USA.
3
Department of Cardiology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
4
Zhongshan-Xuhui Hospital, Fudan University/Shanghai Clinical Research Center, Chinese Academy of Sciences, Shanghai, China. 13361801366@126.com.

Abstract

Every year, millions of people around the world suffer from different forms of tissue trauma. Regenerative medicine refers to therapy that replaces the injured organ or cells. Stem cells are the frontiers and hotspots of current regenerative medicine research. Circular RNAs (circRNAs) are essential for the early development of many species. It was found that they could guide stem cell differentiation through interacting with certain microRNAs (miRNAs). Based on this concept, it is meaningful to look into how circRNAs influence stem cells and its role in regenerative medicine. In this chapter we will discuss the functional roles of circRNAs in the prevention, repair, or progression of chronic diseases, through the communication between stem cells.

KEYWORDS:

Circular RNA; Regenerative medicine; Stem cell

PMID:
30259376
DOI:
10.1007/978-981-13-1426-1_24
[Indexed for MEDLINE]

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