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Alzheimers Dement (N Y). 2018 Aug 30;4:473-480. doi: 10.1016/j.trci.2018.02.003. eCollection 2018.

Cognitive and structural cerebral changes in amnestic mild cognitive impairment due to Alzheimer's disease after multicomponent training.

Author information

1
Neuroimage Laboratory (LNI), Department of Neurology, Medical Sciences Faculty, UNICAMP, Campinas, São Paulo, Brazil.
2
Brazilian Institute of Neuroscience and Neurotechnology, Campinas, São Paulo, Brazil.
3
Medical Physics Laboratory, Department of Neurology, Medical Sciences Faculty, UNICAMP, Campinas, São Paulo, Brazil.
4
Department of Health and Human Services, National Institute on Aging, National Institute of Health, Bethesda, MD, USA.
5
Cardiovascular Department, Medical Sciences Faculty, UNICAMP, Campinas, São Paulo, Brazil.
6
Neuroscience Laboratory (LIM-27), Department and Institute of Psychiatry, São Paulo University (USP), São Paulo, Brazil.
7
Department of Sport Science, Physical Education Faculty, UNICAMP, Campinas, São Paulo, Brazil.

Abstract

Introduction:

Information about how physical exercise affects patients with amnestic mild cognitive impairment (aMCI) due to Alzheimer's disease (AD) is still missing. This study evaluated the impact of multicomponent exercise training on cognition and brain structure in aMCI subjects with cerebral spinal fluid positive AD biomarkers.

Methods:

Forty aMCI subjects were divided in training (multicomponent exercise thrice a week for 6 months) and nontraining groups. Assessments included cardiorespiratory fitness, neurocognitive tests, and a structural magnetic resonance imaging using 3.0 T scanner. FreeSurfer software analyzed hippocampal volume and cortical thickness.

Results:

The training group showed increased volume in both hippocampi and better performance in episodic memory test after 6 months. In contrast, the nontraining group declined in functional activities, recognition, and cardiorespiratory fitness for the same period.

Discussion:

Multicomponent exercise seems to improve hippocampal volume and episodic memory, and maintains VO2max in aMCI due to AD.

KEYWORDS:

Cognition; Cortical thickness; Hippocampus; Multicomponent exercise; aMCI due to AD

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