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Genes Dis. 2016 Dec 14;4(1):19-24. doi: 10.1016/j.gendis.2016.11.003. eCollection 2017 Mar.

The role of hypoxia-inducible factors in tumor angiogenesis and cell metabolism.

Lv X1,2, Li J3, Zhang C1, Hu T1, Li S1, He S1, Yan H1, Tan Y1, Lei M4, Wen M1, Zuo J1,2.

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The Affiliated Nanhua Hospital, University of South China, Hengyang, Hunan 421001, China.
School of Medicine, University of South China, Hengyang, Hunan 421001, China.
Medical School, Shaoyang University, Shaoyang, Hunan 422000, China.
Department of Respiratory and Critical Care Medicine, Zhangjiajie City Hospital, Zhangjiajie, Hunan 427000, China.


Hypoxia-inducible factor (HIF) is a main heterodimeric transcription factor that regulates the cellular adaptive response to hypoxia by stimulating the transcription of a series of hypoxia-inducible genes. HIF is frequently upregulated in solid tumors, and the overexpression of HIF can promote tumor progression or aggressiveness by blood vessel architecture and altering cellular metabolism. In this review, we focused on the pivotal role of HIF in tumor angiogenesis and energy metabolism. Furthermore, we also emphasized the possibility of HIF pathway as a potential therapeutic target in cancer.


Angiogenesis; HIF; Hypoxia; Metabolism; VHL

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