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Nat Neurosci. 2018 Oct;21(10):1471-1481. doi: 10.1038/s41593-018-0239-5. Epub 2018 Sep 26.

Triple dissociation of attention and decision computations across prefrontal cortex.

Author information

1
Sobell Department of Motor Neuroscience, University College London, London, UK. laurence.hunt@psych.ox.ac.uk.
2
Wellcome Centre for Human Neuroimaging, University College London, London, UK. laurence.hunt@psych.ox.ac.uk.
3
Wellcome Centre for Integrative Neuroimaging, University of Oxford, Oxford, UK. laurence.hunt@psych.ox.ac.uk.
4
Oxford Health NHS Foundation Trust, Oxford, UK. laurence.hunt@psych.ox.ac.uk.
5
Sobell Department of Motor Neuroscience, University College London, London, UK.
6
Wellcome Centre for Human Neuroimaging, University College London, London, UK.
7
International Neuroscience Doctoral Programme, Champalimaud Foundation, Lisbon, Portugal.
8
Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal.
9
Wellcome Centre for Integrative Neuroimaging, University of Oxford, Oxford, UK.
10
Sobell Department of Motor Neuroscience, University College London, London, UK. s.kennerley@ucl.ac.uk.

Abstract

Naturalistic decision-making typically involves sequential deployment of attention to choice alternatives to gather information before a decision is made. Attention filters how information enters decision circuits, thus implying that attentional control may shape how decision computations unfold. We recorded neuronal activity from three subregions of the prefrontal cortex (PFC) while monkeys performed an attention-guided decision-making task. From the first saccade to decision-relevant information, a triple dissociation of decision- and attention-related computations emerged in parallel across PFC subregions. During subsequent saccades, orbitofrontal cortex activity reflected the value comparison between currently and previously attended information. In contrast, the anterior cingulate cortex carried several signals reflecting belief updating in light of newly attended information, the integration of evidence to a decision bound and an emerging plan for what action to choose. Our findings show how anatomically dissociable PFC representations evolve during attention-guided information search, supporting computations critical for value-guided choice.

PMID:
30258238
PMCID:
PMC6331040
DOI:
10.1038/s41593-018-0239-5
[Indexed for MEDLINE]
Free PMC Article

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