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Chemistry. 2019 Jan 2;25(1):195-199. doi: 10.1002/chem.201804704. Epub 2018 Nov 20.

Surface-Active Fluorinated Quantum Dots for Enhanced Cellular Uptake.

Author information

1
Institute of Fine Chemistry and Nanochemistry, Department of Physical Chemistry and Applied Thermodynamics, University of Córdoba, Campus de Rabanales, Edificio Marie Curie, 14014, Córdoba, Spain.
2
Biofisika Institute (CSIC, UPV/EHU) and Department of Biochemistry and Molecular Biology, University of the Basque Country UPV/EHU, Barrio Sarriena s/n, 48940, Leioa, Spain.
3
Ikerbasque, Basque Foundation for Science, Maria Diaz de Haro 3,6 solaiura, 48011, Bilbao, Spain.
4
Center for Cooperative Research in Biomaterials (CIC biomaGUNE), Paseo Miramón 182, 20014, San Sebastian, Spain.
5
Center for Research in Biological Chemistry and Molecular Materials (CiQUS), University of Santiago de Compostela, Jenaro de la Fuente s/n, 15782, Santiago de Compostela, Spain.

Abstract

Fluorescent nanoparticles, such as quantum dots, hold great potential for biomedical applications, mainly sensing and bioimaging. However, the inefficient cell uptake of some nanoparticles hampers their application in clinical practice. Here, the effect of the modification of the quantum dot surface with fluorinated ligands to increase their surface activity and, thus, enhance their cellular uptake was explored.

KEYWORDS:

Langmuir monolayer; cell uptake; fluorine; quantum dots; surface activity

PMID:
30257052
DOI:
10.1002/chem.201804704

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