Format

Send to

Choose Destination
Soc Cogn Affect Neurosci. 2018 Nov 8;13(11):1191-1201. doi: 10.1093/scan/nsy087.

Early maternal care may counteract familial liability for psychopathology in the reward circuitry.

Author information

1
Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim / Heidelberg University, J5, Mannheim, Germany.
2
Department of Biostatistics, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, J5, Mannheim, Germany.
3
University Outpatient Clinic of the Institute for Psychiatric and Psychosomatic Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim / Heidelberg University, J5, Mannheim, Germany.
4
Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim / Heidelberg University, J5, Mannheim, Germany.
5
Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Goethe-Universität Frankfurt am Main,Hoffmann-Str. 10, Frankfurt am Main, Germany.
6
Department of Psychology, University of Potsdam, Karl-Liebknecht-Str. 24-25. OT Golm, Potsdam, Germany.
7
Department of Child and Adolescent Psychiatry, University of Zurich, Neumünsterallee 9, Zurich, Switzerland.
8
Center for Integrative Human Physiology, University of Zurich, Winterthurerstr. 190, Zurich, Switzerland.
9
Neuroscience Center Zurich, University of Zurich and ETH Zurich,Winterthurerstrasse 190, Zurich, Switzerland.

Abstract

Reward processing is altered in various psychopathologies and has been shown to be susceptible to genetic and environmental influences. Here, we examined whether maternal care may buffer familial risk for psychiatric disorders in terms of reward processing. Functional magnetic resonance imaging during a monetary incentive delay task was acquired in participants of an epidemiological cohort study followed since birth (N = 172, 25 years). Early maternal stimulation was assessed during a standardized nursing/playing setting at the age of 3 months. Parental psychiatric disorders (familial risk) during childhood and the participants' previous psychopathology were assessed by diagnostic interview. With high familial risk, higher maternal stimulation was related to increasing activation in the caudate head, the supplementary motor area, the cingulum and the middle frontal gyrus during reward anticipation, with the opposite pattern found in individuals with no familial risk. In contrast, higher maternal stimulation was associated with decreasing caudate head activity during reward delivery and reduced levels of attention deficit hyperactivity disorder (ADHD) in the high-risk group. Decreased caudate head activity during reward anticipation and increased activity during delivery were linked to ADHD. These findings provide evidence of a long-term association of early maternal stimulation on both adult neurobiological systems of reward underlying externalizing behavior and ADHD during development.

PMID:
30257014
PMCID:
PMC6234324
DOI:
10.1093/scan/nsy087
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Silverchair Information Systems Icon for PubMed Central
Loading ...
Support Center