Phase 1 safety and pharmacokinetic study on the use of pioglitazone in critically ill patients with sepsis: a randomized clinical trial

Affiliations

• ¹ Division of Critical Care Medicine, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, 3333 Burnet Avenue, MLC 2005, Cincinnati, OH, 45229, USA. Jennifer.kaplan@cchmc.org.
• ² Division of Critical Care Medicine, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, 3333 Burnet Avenue, MLC 2005, Cincinnati, OH, 45229, USA.
• ³ Investigational Pharmacy, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
• ⁴ Division of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
• ⁵ Division of Biostatistics and Epidemiology Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA.