Format

Send to

Choose Destination
Gynecol Minim Invasive Ther. 2018 Jul-Sep;7(3):114-118. doi: 10.4103/GMIT.GMIT_57_18. Epub 2018 Aug 23.

Effect of Vaginal Estriol Use in Total Laparoscopic Hysterectomy with Gonadotropin-Releasing Hormone Agonist Therapy.

Author information

1
Department of Gynecology, Yokohama City University Medical Center, Yokohama, Kanagawa, Japan.
2
Department of Gynecology and Obstetrics, Yokohama Municipal Citizen's Hospital, Yokohama, Kanagawa, Japan.

Abstract

Study Objectives:

The aim of this study is to evaluate the effects of vaginal estriol therapy in total laparoscopic hysterectomy (TLH) with gonadotropin-releasing hormone agonist (GnRH-a) treatment.

Design:

Retrospective analysis.

Design Classification:

Canadian Task Force classification II-2.

Settings:

Department of Gynecology, Yokohama City University Medical Center, Japan.

Methods:

We retrospectively investigated 50 fibroid cases that had TLH with preoperative GnRH-a treatment and compared the surgical outcome with or without vaginal estriol use (1mg). Estriol was used administered for two weeks before TLH.

Measurements and Main Results:

A total of 12 patients (27%) received vaginal estriol (1 mg) for 14 days before TLH. As a result of vaginal estriol treatment, there were no group differences in uterus size reduction with GnRH-a treatment (22% vs. 15%, P = 0.20), uterine removal time through the vagina (12.5 min vs. 18.5 min, P = 0.18), rate of vaginal dehiscence (3% vs. 0%, P = 0.76) or in the rate of perineal laceration (33% vs. 34%, P = 0.55).

Conclusion:

The use of vaginal estriol treatment before TLH with GnRH-a therapy did not improve surgical outcomes.

KEYWORDS:

Estriol; gonadotropin-releasing hormone agonist; laparoscopic hysterectomy

Supplemental Content

Full text links

Icon for Medknow Publications and Media Pvt Ltd Icon for PubMed Central
Loading ...
Support Center