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Gut Microbes. 2019;10(2):246-250. doi: 10.1080/19490976.2018.1513765. Epub 2018 Sep 25.

Dietary destabilisation of the balance between the microbiota and the colonic mucus barrier.

Author information

1
a Department of Medical Biochemistry , University of Gothenburg , Gothenburg , Sweden.
2
b Department of Molecular and Clinical Medicine , University of Gothenburg , Gothenburg , Sweden.

Abstract

It has long been acknowledged that dietary fibres are important to maintain a healthy gut. Over the past decade, several studies have shown that loss of complex polysaccharides from the Western diet has resulted in alterations to our colonic microbiota. The concurrent increase in the incidence of inflammatory bowel disease in the Western world has driven us to explore the potential mechanistic link between diet, the microbiota and the host defence systems that normally prevent inflammation. Using mice fed a low fibre Western-style diet and robust live tissue analytical methods we have now provided evidence that this diet impairs the colonic inner mucus layer that normally separates bacteria from host cells. Western societies urgently need to develop their understanding of the molecular mechanisms of the diet-microbiota-mucus axis and its implications for inflammatory diseases.

KEYWORDS:

Colon; diet; fiber; inflammation; microbiota; mucin; mucus; ulcerative colitis

PMID:
30252606
PMCID:
PMC6546334
DOI:
10.1080/19490976.2018.1513765
[Indexed for MEDLINE]
Free PMC Article

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