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Curr Diab Rep. 2018 Sep 24;18(11):112. doi: 10.1007/s11892-018-1085-2.

The Impact of Pancreatic Beta Cell Heterogeneity on Type 1 Diabetes Pathogenesis.

Author information

1
Department of Bioengineering, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA.
2
Barbara Davis Center for Childhood Diabetes, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA.
3
Oregon Stem Cell Center, Papé Family Pediatric Research Institute, Department of Pediatrics, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR, 97239, USA.
4
Institute of Metabolism and Systems Research (IMSR), University of Birmingham, Birmingham, B15 2TT, UK. d.hodson@bham.ac.uk.
5
Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham, B15 2TH, UK. d.hodson@bham.ac.uk.
6
COMPARE, University of Birmingham and University of Nottingham Midlands, Nottingham, UK. d.hodson@bham.ac.uk.
7
Section of Cell Biology and Functional Genomics, Department of Medicine, Imperial College London, London, W12 0NN, UK.

Abstract

PURPOSE OF REVIEW:

To discuss advances in our understanding of beta-cell heterogeneity and the ramifications of this for type 1 diabetes (T1D) and its therapy.

RECENT FINDINGS:

A number of studies have challenged the long-standing dogma that the majority of beta cells are eliminated in T1D. As many as 80% are present in some T1D subjects. Why don't these cells function properly to release insulin in response to high glucose? Other findings deploying single-cell "omics" to study both healthy and diseased cells-from patients with both T1D and type 2 diabetes (T2D)-have revealed cell subpopulations and heterogeneity at the transcriptomic/protein level between individual cells. Finally, our own and others' findings have demonstrated the importance of functional beta-cell subpopulations for insulin secretion. Heterogeneity may endow beta cells with molecular features that predispose them to failure/death during T1D.

KEYWORDS:

Beta cell; Heterogeneity; Imaging; Insulin; Transcriptomics; Type 1 diabetes

PMID:
30251179
PMCID:
PMC6153573
DOI:
10.1007/s11892-018-1085-2
[Indexed for MEDLINE]
Free PMC Article

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