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Mol Cell Oncol. 2018 Aug 6;5(4):e1472059. doi: 10.1080/23723556.2018.1472059. eCollection 2018.

What a dog transmissible tumor can teach us about cancer regression.

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Division of Infection & Immunity, University College London, London, UK.


The canine transmissible venereal tumor (CTVT) is one of the few clonally transmissible cancers in nature and the only one that fully regresses following treatment with vincristine. The molecular signature of CTVT regression has been described in a recent paper published in Cancer Cell, revealing some fundamental insights into cancer regression.


Biology of malignant cells; CCL5; cancer; chemotherapy; dog; inflammation; regression; rejection; transmissible

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