The Cohesion complex maintains genome stability by preventing end joining of distant DNA ends in S phase

Camille Gelot; Josée Guirouilh-Barbat; Bernard S Lopez

doi:10.1080/23723556.2016.1154123

The Cohesion complex maintains genome stability by preventing end joining of distant DNA ends in S phase

Mol Cell Oncol. 2018 Apr 19;5(3):e1154123. doi: 10.1080/23723556.2016.1154123. eCollection 2018.

Authors

Camille Gelot¹, Josée Guirouilh-Barbat¹, Bernard S Lopez¹

Affiliation

¹ CNRS UMR 8200, Institut de Cancérologie Gustave-Roussy, Université Paris-Saclay, Equipe Labellisée Ligue Contre le Cancer, 114 Rue Edouard Vaillant, Villejuif, France.

Abstract

Genome instability is a hallmark of cancer cells. The joining of distant DNA double-strand ends (DSEs) ineluctably leads to genome rearrangements. We found that the cohesion complex maintains genome stability by repressing the joining of distant DSEs specifically in the S phase, i.e., the main phase producing one-ended DSEs.

Keywords: Cohesin; NHEJ; double-strand break repair; genome rearrangements; replication stress.

Grants and funding

This work was supported by funding from the Ligue Nationale Française Contre le Cancer, ANR (Agence Nationale de la Recherche, ANR-14-CE10-0010-02), AFM-Téléthon and INCa (Institut National du Cancer, 2011-1-RT-01, 2011-1-PLBIO-09, 2013-1-PLBIO-14).