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Pediatr Res. 2018 Dec;84(6):854-860. doi: 10.1038/s41390-018-0170-1. Epub 2018 Sep 13.

Prenatal exposure to perfluoroalkyl substances and adipocytokines: the HOME Study.

Author information

1
Department of Pediatrics, Warren Alpert Medical School of Brown University, Providence, RI, USA. catybuck@gmail.com.
2
Department of Epidemiology, Brown University School of Public Health, Providence, RI, USA.
3
Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, USA.
4
Department of Environmental Health, University of Cincinnati, Cincinnati, OH, USA.
5
Division of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
6
Faculty of Health and Sciences, Simon Fraser University, Burnaby, Canada.

Abstract

OBJECTIVE:

Gestational perfluoroalkyl substances exposure has been associated with decreased birthweight. We determined if gestational perfluoroalkyl substances exposure was associated with fetal metabolic markers using data from the HOME Study, a prospective birth cohort of pregnant women and their children in Cincinnati, Ohio.

METHODS:

Maternal serum concentrations of perfluorooctanoic acid (PFOA), perfluorooctane sulfonic acid (PFOS), perfluorononanoic acid, and perfluorohexane sulfonic acid were quantified. We measured neonatal adipocytokine (leptin and adiponectin) concentrations in umbilical cord serum, and estimated percent differences with a 2-fold increase in maternal perfluoroalkyl substances concentrations among 230 mother-infant pairs.

RESULTS:

Median maternal serum PFOA and PFOS concentrations were 5.6 ng/mL and 14 ng/mL, respectively. Leptin was positively correlated with infant birthweight (p < 0.001). There were no statistically significant associations between maternal perfluoroalkyl substances and neonatal adipocytokine concentrations; each 2-fold increase in PFOA was associated with a non-significant increase in leptin (5%; 95% CI: -10, 22) and adiponectin (7%; 95% CI: -4, 19).

CONCLUSION:

Despite known associations with reduced birthweight, gestational serum perfluoroalkyl substances concentrations were not associated with neonatal adipocytokine concentrations. Further exploration of pathways of perfluoroalkyl substances associated changes in birthweight may help identify biomarkers that could be used to identify at-risk populations and develop interventions.

PMID:
30250302
DOI:
10.1038/s41390-018-0170-1

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