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Nat Commun. 2018 Sep 24;9(1):3891. doi: 10.1038/s41467-018-06393-w.

Maternal gut and breast milk microbiota affect infant gut antibiotic resistome and mobile genetic elements.

Author information

1
Department of Microbiology, University of Helsinki, Viikinkaari 9, Helsinki, 00014, Finland. katariina.parnanen@helsinki.fi.
2
Department of Infectious Diseases, Institute of Biomedicine, The Sahlgrenska Academy, University of Gothenburg, Guldhedsgatan 10, SE-413 46, Gothenburg, Sweden.
3
Center for Antibiotic Resistance research (CARe) at University of Gothenburg, P.O. Box 440, SE-40530, Gothenburg, Sweden.
4
Faculty of Biological and Environmental Sciences, University of Helsinki, 00014, Helsinki, Finland.
5
Department of Microbiology, University of Helsinki, Viikinkaari 9, Helsinki, 00014, Finland.
6
Wisconsin Institute for Discovery, University of Wisconsin-Madison, 330N. Orchard Street, Madison, WI, 53715, USA.
7
University of Turku and Turku University Hospital, 20500, Turku, Finland.
8
Functional Foods Forum, Faculty of medicine, University of Turku, Turku, 20520, Finland.
9
Immunobiology Research Program, Faculty of Medicine, University of Helsinki, Helsinki, 00014, Finland.

Abstract

The infant gut microbiota has a high abundance of antibiotic resistance genes (ARGs) compared to adults, even in the absence of antibiotic exposure. Here we study potential sources of infant gut ARGs by performing metagenomic sequencing of breast milk, as well as infant and maternal gut microbiomes. We find that fecal ARG and mobile genetic element (MGE) profiles of infants are more similar to those of their own mothers than to those of unrelated mothers. MGEs in mothers' breast milk are also shared with their own infants. Termination of breastfeeding and intrapartum antibiotic prophylaxis of mothers, which have the potential to affect microbial community composition, are associated with higher abundances of specific ARGs, the composition of which is largely shaped by bacterial phylogeny in the infant gut. Our results suggest that infants inherit the legacy of past antibiotic consumption of their mothers via transmission of genes, but microbiota composition still strongly impacts the overall resistance load.

PMID:
30250208
PMCID:
PMC6155145
DOI:
10.1038/s41467-018-06393-w
[Indexed for MEDLINE]
Free PMC Article

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