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Antimicrob Agents Chemother. 2018 Nov 26;62(12). pii: e01716-18. doi: 10.1128/AAC.01716-18. Print 2018 Dec.

In Vivo Efficacy of Ellagic Acid against Candida albicans in a Drosophila melanogaster Infection Model.

Author information

1
Department of Environmental Engineering and Oral Biopathology Graduate Program, São José dos Campos Institute of Science and Technology, Universidade Estadual Paulista (UNESP), São José dos Campos, Brazil.
2
Institute of Biomedical Sciences, Federal University of Rio de Janeiro (UFRJ), National Institute of Science and Technology in Molecular Entomology (INCT-EM), Rio de Janeiro, Brazil.
3
Department of Environmental Engineering and Oral Biopathology Graduate Program, São José dos Campos Institute of Science and Technology, Universidade Estadual Paulista (UNESP), São José dos Campos, Brazil aline.gontijo@gmail.com.

Abstract

The aim of this study was to evaluate the antifungal activity and the toxicity of ellagic acid (EA) using a Drosophila melanogaster model. Candida albicans bacteria were inoculated into Toll heterozygous flies. Survival curves were obtained for the evaluation of the antimicrobial effect and toxicity of EA. A protective effect of EA against fungal infection in Drosophila melanogaster was observed at nontoxic concentrations. This study showed that EA is a promising tool for the treatment of candidiasis.

KEYWORDS:

Candida albicans ; Drosophila melanogaster ; candidiasis; ellagic acid

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